Efinaconazole

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$400	Check With Us
2g	$650	Check With Us
5g	$1050	Check With Us

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Cat #: V20179 CAS #: 164650-44-6 Purity ≥ 99%

Description: Efinaconazole(formerly AGJ-95634; KP-103; CTK-5J2975; KB-145948; trade names Jublia; Clenafin) is a triazole antifungal drug approved for use in various countries such as the United States, Canada, and Japan as a 10% topical solution for the treatment of onychomycosis (fungal infection of the nails).

References: Tatsum Y, et al. KP-103, a novel triazole derivative, is effective in preventing relapse and successfully treating experimental interdigital tinea pedis and tinea corporis in guinea pigs. Microbiol Immunol. 2002;46(7):425-32.

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Protocol
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Stock Solution Preparation
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Molecular Weight (MW)	348.39
Molecular Formula	C18H22F2N4O
CAS No.	164650-44-6
Synonyms	AGJ95634; KP103; CTK5J2975; KB145948; AGJ-95634; KP-103; CTK-5J2975; KB-145948; AGJ 95634; KP 103; CTK 5J2975; KB 145948; trade names Jublia

Protocol	In Vivo	Topical Efinaconazole solution (0.25 to 1%) is dose-dependently effective in treating both dermatophytoses, for 10 guinea pigs with interdigital tinea pedis or tinea corporis is investigated. The follow up study performs on day-30 and day-9 posttreatment demonstrated that the relapse rates for 1% Efinaconazole-treated animals with tinea pedis and for those with tinea corporis are 20 and 30%, respectively. When a single dose of 1% Efinaconazole is applied to the back skin 48 hours before fungal inoculation, 9 of the 10 animals are protected from the dermatophytosis, suggesting that active Efinaconazole is retained in skin tissue for at least 48 hours after dosing

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8703 mL	14.3517 mL	28.7035 mL	57.4069 mL
5mM	0.5741 mL	2.8703 mL	5.7407 mL	11.4814 mL
10mM	0.2870 mL	1.4352 mL	2.8703 mL	5.7407 mL
20mM	0.1435 mL	0.7176 mL	1.4352 mL	2.8703 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.