Efaproxiral (RSR13)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | Check With Us |
| 1g | $650 | Check With Us |
| 5g | $1645 | Check With Us |
: Cat #: V20405 CAS #: 131179-95-8 Purity ≥ 98%
Description: Efaproxiral (RSR13) is a synthetic allosteric modifier of hemoglobin (Hb) and a bezafibrate analog used for brain metastases originating from breast cancer.
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| Molecular Weight (MW) | 341.40 |
|---|---|
| Molecular Formula | C20H23NO4 |
| CAS No. | 131179-95-8 |
| SMILES Code | CC(C)(OC1=CC=C(CC(NC2=CC(C)=CC(C)=C2)=O)C=C1)C(O)=O |
| Synonyms | NSC722758; NSC-722758; NSC 722758; RSR13; RSR-13; RSR 13; Efaproxiral; Efaproxyn; |
| Protocol | In Vitro | Efaproxiral binds to only one pair of symmetry-related sites in the Hb central water cavity. |
|---|---|---|
| In Vivo | Efaproxiral (150 mg/kg, i.p.) increase tumor oxygenation，and increase the tumor growth inhibition of radiotherapy over 5 days of treatment. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9291 mL | 14.6456 mL | 29.2912 mL | 58.5823 mL |
| 5mM | 0.5858 mL | 2.9291 mL | 5.8582 mL | 11.7165 mL |
| 10mM | 0.2929 mL | 1.4646 mL | 2.9291 mL | 5.8582 mL |
| 20mM | 0.1465 mL | 0.7323 mL | 1.4646 mL | 2.9291 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.