E3 Ligase Ligand-Linker Conjugates 2

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$850	Check With Us
500mg	$1350	Check With Us
1g	$2025	Check With Us

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Cat #: V32177 CAS #: 1818885-63-0 Purity ≥ 99%

Description: E3 Ligase Ligand-Linker Conjugates 2,(Pomalidomide-PEG4-Ph-NH2, Cereblon Ligand-Linker Conjugates 9)incorporates a ligand for the E3 ubiquitin ligase, and a PROTAC linker, which bring together target protein and ubiquitinating machinery.

References: Andrew P. Crew, et al. Imide-based modulators of proteolysis and associated methods of use. US20160058872A1.

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Molecular Weight (MW)	540.57
Molecular Formula	C27H32N4O8
CAS No.	1818885-63-0
SMILES Code	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOC4=CC=C(N)C=C4)=O
Synonyms	E3 Ligase Ligand-Linker Conjugates 2

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8499 mL	9.2495 mL	18.4990 mL	36.9980 mL
5mM	0.3700 mL	1.8499 mL	3.6998 mL	7.3996 mL
10mM	0.1850 mL	0.9249 mL	1.8499 mL	3.6998 mL
20mM	0.0925 mL	0.4625 mL	0.9249 mL	1.8499 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.