Droloxifene (3-Hydroxytamoxifen)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $990 | Check With Us |
| 200mg | $1485 | Check With Us |
| 500mg | $2505 | Check With Us |
: Cat #: V20253 CAS #: 82413-20-5 Purity ≥ 98%
Description: Droloxifene (3-Hydroxytamoxifen) is a tamoxifen analogue and orally bioactive SERM (selective estrogen receptor modulator) that acts as an ER agonist in bone and as an ER antagonist in breast tissue.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 387.51 |
|---|---|
| Molecular Formula | C26H29NO2 |
| CAS No. | 82413-20-5 |
| SMILES Code | OC1=CC=CC(/C(C2=CC=C(OCCN(C)C)C=C2)=C(C3=CC=CC=C3)CC)=C1 |
| Synonyms | Droloxifene; K060E; K 21060E; K 21060E; K 060E; K-060E; |
| Protocol | In Vitro | Droloxifene (10 nM; 16-18 hours) induces apoptosis in MCF-7 cells. |
|---|---|---|
| In Vivo | Droloxifene (5-20 mg/kg; p.o.; daily for 4 weeks) increases BMD of DFM at 10mg/kg, and completely prevents the decrease of BMC and BMD of DFM induced by ovariectomized (OVX) at 20 mg/kg/day. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5806 mL | 12.9029 mL | 25.8058 mL | 51.6116 mL |
| 5mM | 0.5161 mL | 2.5806 mL | 5.1612 mL | 10.3223 mL |
| 10mM | 0.2581 mL | 1.2903 mL | 2.5806 mL | 5.1612 mL |
| 20mM | 0.1290 mL | 0.6451 mL | 1.2903 mL | 2.5806 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.