Doxorubicin-SMCC

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1250	Check With Us
200mg	$1875	Check With Us
500mg	$3200	Check With Us

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Cat #: V20208 CAS #: 400647-59-8 Purity ≥ 99%

Description: Doxorubicin-SMCC (dox-SMCC); ADR-SMCC) is a doxorubicin analog used as drug-linker conjugate for the synthesis of antibody-drug-conjugates (ADC). In Doxorubicin-SMCC, Doxorubicin is connected to a linker called SMCC (Succinimidyl-4-( N -maleimidomethyl)cyclohexane-1-carboxylate) and thus can be used to prepare doxorubicin-based bioconjugated compounds such as ADCs.

References: [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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Molecular Weight (MW)	762.76
Molecular Formula	C39H42N2O14
CAS No.	400647-59-8
SMILES Code	C[C@@H]1O[C@@H](O[C@@H](C2)C3=C(O)C(C4=O)=C(C(C5=C4C(OC)=CC=C5)=O)C(O)=C3C[C@@]2(O)C(CO)=O)C[C@H](NC(C6CCC(CN7C(C=CC7=O)=O)CC6)=O)[C@@H]1O
Synonyms	Dox-SMCC Doxo-SMCC; Doxorubicin-SMCC; ADR-SMCC;

Protocol	In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linke.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3110 mL	6.5551 mL	13.1103 mL	26.2206 mL
5mM	0.2622 mL	1.3110 mL	2.6221 mL	5.2441 mL
10mM	0.1311 mL	0.6555 mL	1.3110 mL	2.6221 mL
20mM	0.0656 mL	0.3278 mL	0.6555 mL	1.3110 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.