Dorzolamide
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $850 | Check With Us |
| 2g | $1350 | Check With Us |
| 5g | $2275 | Check With Us |
: Cat #: V14925 CAS #: 120279-96-1 Purity ≥ 99%
Description: Dorzolamide (L671152; MK507; L671152; MK507; Trusopt) is a CAI (carbonic anhydrase inhibitors) approved for use as an anti-glaucoma agent.
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| Molecular Weight (MW) | 324.44 |
|---|---|
| Molecular Formula | C10H16N2O4S3 |
| CAS No. | 120279-96-1 |
| SMILES Code | O=S(C(S1)=CC([C@@H](NCC)C[C@@H]2C)=C1S2(=O)=O)(N)=O |
| Synonyms | UNII-9JDX055TW1; Dorzolamide; UNII 9JDX055TW1; UNII9JDX055TW1; |
| Protocol | In Vitro | Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM). |
|---|---|---|
| In Vivo | Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0822 mL | 15.4112 mL | 30.8223 mL | 61.6447 mL |
| 5mM | 0.6164 mL | 3.0822 mL | 6.1645 mL | 12.3289 mL |
| 10mM | 0.3082 mL | 1.5411 mL | 3.0822 mL | 6.1645 mL |
| 20mM | 0.1541 mL | 0.7706 mL | 1.5411 mL | 3.0822 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.