Dorzagliatin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | Check With Us |
| 500mg | $2200 | Check With Us |
| 1g | $3300 | Check With Us |
: Cat #: V20192 CAS #: 1191995-00-2 Purity ≥ 98%
Description: Dorzagliatin (RO-5305552; HMS-5552; sinogliatin) is an investigational antidiabetic agent acting as a dual-acting glucokinase activator (GKA) that is able to improves glycaemic control and pancreatic β-cell function in type 2 diabete.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 462.93 |
|---|---|
| Molecular Formula | C22H27ClN4O5 |
| CAS No. | 1191995-00-2 |
| SMILES Code | CC(C)C[C@H](N1C(C=C(OC2=CC=CC=C2Cl)C1)=O)C(NC3=NN(C[C@@H](O)CO)C=C3)=O |
| Synonyms | Dorzagliatin; HMS 5552; HMS-5552; HMS5552; RO5305552; RO-5305552; RO 5305552; Sinogliatin-isomer |
| Protocol | In Vivo | Dorzagliatin (low-dose 10 mg/kg, and high-dose 30 mg/kg; administered intragastrically; daily 8:00 AM for one month) exerts a glucose-lowering effect on the glucose levels in diabetic rats. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1602 mL | 10.8008 mL | 21.6015 mL | 43.2031 mL |
| 5mM | 0.4320 mL | 2.1602 mL | 4.3203 mL | 8.6406 mL |
| 10mM | 0.2160 mL | 1.0801 mL | 2.1602 mL | 4.3203 mL |
| 20mM | 0.1080 mL | 0.5400 mL | 1.0801 mL | 2.1602 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.