Doramectin | CAS 117704-25-3

Doramectin

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$300	Check With Us
1g	$480	Check With Us
5g	$1215	Check With Us

: [email protected] [email protected]

Cat #: V7773 CAS #: 117704-25-3 Purity ≥ 98%

Description: Doramectin is a potent antiparasitic drug used for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.

References: Rodgers W, et al. Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus,Streptococcus pneumoniae, and Haemophilus influenzae. Antimicrob Agents Chemother. 2013 Apr;57(4):1632-1637.

Top Publications Citing Invivochem Products

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	845.01
Molecular Formula	C43H65FN6O10
CAS No.	117704-25-3
SMILES Code	CC[C@@H]1[C@]2(C)[C@H](N(CCCCN3C=C(C4=CC(N)=CC=C4)N=N3)C(O2)=O)[C@H](C)C([C@H](C)C[C@@](C)(OC)[C@H](O[C@H]5[C@H](O)[C@@H](N(C)C)C[C@@H](C)O5)[C@@H](C)C([C@@](C)(F)C(O1)=O)=O)=O
Synonyms	OP 1068; Solithromycin; CEM101; CEM101; CEM 101; OP1068; OP1068;

Protocol	In Vitro	Doramectin (10 mg/kg) is active in vivo with worm burden reductions of 60.1% in worm burden reductions of S.mansoni-infected mice.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.1834 mL	5.9171 mL	11.8342 mL	23.6684 mL
5mM	0.2367 mL	1.1834 mL	2.3668 mL	4.7337 mL
10mM	0.1183 mL	0.5917 mL	1.1834 mL	2.3668 mL
20mM	0.0592 mL	0.2959 mL	0.5917 mL	1.1834 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise