Dooku1 (Yoda1 Analog)

This product is for research use only, not for human use. We do not sell to patients.

Dooku1 (Yoda1 Analog)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$500Check With Us
250mg$800Check With Us
500mg$1200Check With Us

Cat #: V31417 CAS #: 2253744-54-4 Purity ≥ 99%

Description: Dooku1, an analog of Yoda1, is a novel, potent and selective antagonist of the endogenous Piezo1 channel.

References: Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759.

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Molecular Weight (MW)326.20
Molecular FormulaC₁₃H₉Cl₂N₃OS
CAS No.2253744-54-4
SynonymsDooku1; Dooku-1; Dooku 1
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0656 mL15.3280 mL30.6560 mL61.3121 mL
5mM0.6131 mL3.0656 mL6.1312 mL12.2624 mL
10mM0.3066 mL1.5328 mL3.0656 mL6.1312 mL
20mM0.1533 mL0.7664 mL1.5328 mL3.0656 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.