DLin-KC2-DMA
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1500 | Check With Us |
| 200mg | $2250 | Check With Us |
| 500mg | $3795 | Check With Us |
: Cat #: V20103 CAS #: 1190197-97-7 Purity ≥ 98%
Description: DLin-KC2-DMA is novel ionizable and cationic lipid useful for siRNA delivery.
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| Molecular Weight (MW) | 642.09 |
|---|---|
| Molecular Formula | C43H79NO2 |
| CAS No. | 1190197-97-7 |
| SMILES Code | CN(CCC1OC(CCCCCCCC/C=C\C/C=C\CCCCC)(CCCCCCCC/C=C\C/C=C\CCCCC)OC1)C |
| Synonyms | DLin-KC2-DMA; D-Lin-KC2-DMA; KC2; |
| Protocol | In Vitro | DLin-KC2-DMA displays almost no toxicity in primary APCs. DLin-KC2-DMA efficiently promotes release of encapsulated siRNA into the cytosol following uptake via the endocytotic pathway. DLin-KC2-DMA (24 h) exhibits high uptake into macrophages and dendritic cells. DLin-KC2-DMA (1, 5 μg; 72 h) effectively produces a significant siRNA-mediated GAPDH gene silencing in both macrophages and dendritic cells. |
|---|---|---|
| In Vivo | DLin-KC2-DMA contained-LNP siRNA systems (5 mg/kg; i.v.; single) effectively silences target genes in APcs in vivo. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5574 mL | 7.7871 mL | 15.5741 mL | 31.1483 mL |
| 5mM | 0.3115 mL | 1.5574 mL | 3.1148 mL | 6.2297 mL |
| 10mM | 0.1557 mL | 0.7787 mL | 1.5574 mL | 3.1148 mL |
| 20mM | 0.0779 mL | 0.3894 mL | 0.7787 mL | 1.5574 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.