Dizocilpine Maleate [(+)-MK 801 maleate]
This product is for research use only, not for human use. We do not sell to patients.
![Dizocilpine Maleate [(+)-MK 801 maleate]](https://invivochem.net/wp-content/uploads/2023/05/CgAGS12jNEiAZ-8yAAAjlahnIBU561.png "Dizocilpine Maleate [(+)-MK 801 maleate]")
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $850 | Check With Us |
| 1g | $1350 | Check With Us |
| 5g | $4050 | Check With Us |
: Cat #: V1083 CAS #: 77086-22-7 Purity ≥ 98%
Description: Dizocilpine Maleate [formerly (+)-MK-801)], the maleate salt of (+)dizocilpine, is a non-competitive antagonist of NMDA (N-Methyl-D-aspartate) receptors with a Kd of 37.2 nM in rat brain membranes.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 337.37 |
|---|---|
| Molecular Formula | C16H15N.C4H4O4 |
| CAS No. | 77086-22-7 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 68 mg/mL (201.6 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol:<1 mg/mL | |
| SMILES Code | CC1(N2)C3=CC=CC=C3CC2C4=CC=CC=C14.O=C(O)/C=C\C(O)=O |
| Synonyms | Dizocilpine; MK801; MK 801; MK-801; MK 801 Maleate |
| Protocol | In Vitro | Dizocilpine maleate (< 500 μM) inhibits activation of microglia induced by LPS with increased Cox-2 protein expression in BV-2 cells. Dizocilpine (MK-801; <500 μM) reduces microglial TNF-α output with an EC50 of 400 μM in BV-2 cells |
|---|---|---|
| In Vivo | Dizocilpine maleate (MK 801 maleate) (1 mg/kg) treatment before each METH injection reduces the extent of DA depletion by 55% in striatal of mice. Dizocilpine (MK 801) (1 mg/kg) also attenuates the effects of METH on microglial activation in striatal of mice |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9641 mL | 14.8205 mL | 29.6410 mL | 59.2821 mL |
| 5mM | 0.5928 mL | 2.9641 mL | 5.9282 mL | 11.8564 mL |
| 10mM | 0.2964 mL | 1.4821 mL | 2.9641 mL | 5.9282 mL |
| 20mM | 0.1482 mL | 0.7410 mL | 1.4821 mL | 2.9641 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.