Diphenhydramine HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$150	Check With Us
25g	$280	Check With Us
50g	$420	Check With Us

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Cat #: V1221 CAS #: 147-24-0 Purity ≥ 98%

Description: Diphenhydramine HCl (Dabylen; PM255; PM-255; Debendrin; Difenhydramine), the hydrochloride salt of diphenhydramine, is a 1st-generation histamine H1 receptor antagonist which was approved as an antiemetic for treating various allergic conditions such as rhinitis, urticaria and conjunctivitis.

References: Simons FE. H1-receptor antagonists. Comparative tolerability and safety. Drug Saf. 1994;10(5):350-380.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	291.82
Molecular Formula	C17H21NO.HCl
CAS No.	147-24-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 58 mg/mL (198.8 mM)r
	Water: 58 mg/mL (198.8 mM)r
	Ethanol: 58 mg/mL (198.8 mM)
Synonyms	PM 255; Diphenhydramine; Dabylen; PM255; PM-255; Debendrin; Difenhydramine.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.4268 mL	17.1338 mL	34.2677 mL	68.5354 mL
5mM	0.6854 mL	3.4268 mL	6.8535 mL	13.7071 mL
10mM	0.3427 mL	1.7134 mL	3.4268 mL	6.8535 mL
20mM	0.1713 mL	0.8567 mL	1.7134 mL	3.4268 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.