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Dimethyl sulfoxide

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Dimethyl sulfoxide
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Cat #: V3365 CAS #: 67-68-5 Purity ≥ 98%

Description: Dimethyl sulfoxide (also known as DMSO or Methyl Sulfoxide) is an aprotic solvent that dissolves both polar and nonpolar compounds.

References: C F Brayton. Dimethyl sulfoxide (DMSO): a review. Cornell Vet. 1986 Jan;76(1):61-90.

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Molecular Weight (MW)78.13
Molecular FormulaC2H6OS
CAS No.67-68-5
SynonymsDimethyl sulfoxide ;DMSO ; Methyl Sulfoxide
ProtocolIn VitroDMSO is an organic solvent that is freely miscible with water, lipids and organic agents. These properties allow for exceptional membrane penetration. The mechanism of action of DMSO is thought to be a combination of anti-inflammatory effects, nerve blockade, smooth muscle relaxation, and collagen inhibition.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM12.7992 mL63.9959 mL127.9918 mL255.9836 mL
5mM2.5598 mL12.7992 mL25.5984 mL51.1967 mL
10mM1.2799 mL6.3996 mL12.7992 mL25.5984 mL
20mM0.6400 mL3.1998 mL6.3996 mL12.7992 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.