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Dihexa

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Dihexa
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Size Price Stock
500mg$800In Stock
1g$1200In Stock
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Cat #: V15953 CAS #: 1401708-83-5 Purity ≥ 98%

Description: Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a novel, potent, oral, brain-permeable oligopeptide drug derived from angiotensin IV that binds with high affinity (Kd = 65 pM) to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. Dihexa has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor.

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Molecular FormulaC27H44N4O5
CAS No.1401708-83-5
SMILES CodeO=C(N)CCCCCNC([C@@H](NC([C@@H](NC(CCCCC)=O)CC1=CC=C(O)C=C1)=O)[C@@H](C)CC)=O           
ProtocolIn VitroDihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a novel, potent, oral, brain-permeable oligopeptide drug derived from angiotensin IV that binds with high affinity (Kd = 65 pM) to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. Both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met[1].
In VivoDihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons[2].
These protocols are for reference only. InvivoChem does not independently validate these methods.
Quality Control Documentation
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