DELAFLOXACIN MEGLUMINE

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$550	Check With Us
500mg	$950	Check With Us
1μg	$1425	Check With Us

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Cat #: V3919 CAS #: 352458-37-8 Purity ≥ 98%

Description: Delafloxacin MEGLUMINE (WQ-3034; ABT-492; RX-3341; WQ3034; ABT492; RX3341; Baxdela), the MEGLUMINE salt of Delafloxacin, is an antibiotic of the quinolone class approved in 2017 by FDA to treat patients with acute bacterial skin infections.

References: Lepak AJ, et al. In Vivo Pharmacodynamic Target Assessment of Delafloxacin against Staphylococcus aureus, Streptococcus pneumoniae, and Klebsiella pneumoniae in a Murine Lung Infection Model. Antimicrob Agents Chemother. 2016 Jul 22;60(8):4764-9.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	635.986
Molecular Formula	C25H29ClF3N5O9
CAS No.	352458-37-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mMr
	Water: N/Ar
	Ethanol: N/A
SMILES Code	CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(C1=CN(C2=NC(N)=C(F)C=C2F)C3=C(C=C(F) C(N4CC(O)C4)=C3Cl)C1=O)O
Synonyms	Trade name. Baxdela; ABT-492; ABT 492 meglumine; ABT492; RX-3341; WQ-3034; RX3341; WQ3034; RX 3341; WQ 3034 meglumine

Protocol	In Vivo	Delafloxacin (2.5, 10, 40, and 160 mg/kg; subcutaneous injection, 24 h) has moderate terminal elimination half-life (t1/2=0.68 h, 0.79 h, 0.69 h and 1.0 h for 2.5 mg/kg, 10 mg/kg, 40 mg/kg, and 160 mg/kg, respectively). Delafloxacin (the total daily doses vary from 0.156 to 640 mg/kg/24 h, subcutaneous injection) is highly effective against S. aureus. Against all four strains are observed a decrease of 1.5 to 2.2 log10 CFU in organism burden from untreated controls at even the lowest dose studied, and for two strains (MW2 and R2527) there is net bactericidal activity at the lowest dose. At the maximal doses studied, there is a >4-log10 kill from initial burden for all S. aureus strains.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5724 mL	7.8618 mL	15.7236 mL	31.4472 mL
5mM	0.3145 mL	1.5724 mL	3.1447 mL	6.2894 mL
10mM	0.1572 mL	0.7862 mL	1.5724 mL	3.1447 mL
20mM	0.0786 mL	0.3931 mL	0.7862 mL	1.5724 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.