Dazoxiben HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $850 | Check With Us |
| 500mg | $1450 | Check With Us |
| 1g | $2175 | Check With Us |
: Cat #: V26981 CAS #: 74226-22-5 Purity ≥ 99%
Description: Dazoxiben HCl is a potent and orally bioactive antithrombotic agent acting as a thromboxane (TX) synthase inhibitor.
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| Molecular Weight (MW) | 268.70 |
|---|---|
| Molecular Formula | C12H13ClN2O3 |
| CAS No. | 74226-22-5 |
| SMILES Code | O=C(O)C1=CC=C(OCCN2C=CN=C2)C=C1.[H]Cl |
| Synonyms | Dazoxiben hydrochloride; Dazoxiben hydrochloride, UK-37248; UK37248; UK-37,248-01; Dazoxiben HCl; Dazoxiben hydrochloride, |
| Protocol | In Vitro | Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1.60 μM) than in rat whole blood (IC50= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production. Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production. |
|---|---|---|
| In Vivo | Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7216 mL | 18.6081 mL | 37.2162 mL | 74.4325 mL |
| 5mM | 0.7443 mL | 3.7216 mL | 7.4432 mL | 14.8865 mL |
| 10mM | 0.3722 mL | 1.8608 mL | 3.7216 mL | 7.4432 mL |
| 20mM | 0.1861 mL | 0.9304 mL | 1.8608 mL | 3.7216 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.