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Dapagliflozin impurity

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Dapagliflozin impurity
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$580Check With Us
100mg$950Check With Us
200mg$1425Check With Us

Cat #: V28639 CAS #: 960404-86-8 Purity ≥ 99%

Description: Dapagliflozin impurity is an isomer of Dapagliflozin which is a SGLT2 (sodium-glucose transporter 2) inhibitor approved in 2012 for the treatment of type 2 diabetes.

References: Kasichayanula S, et al. Lack of pharmacokinetic interaction between dapagliflozin, a novel sodium-glucose transporter 2 inhibitor, and metformin, pioglitazone, glimepiride or sitagliptin in healthy subjects. Diabetes Obes Metab. 2011 Jan;13(1):47-54.

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Molecular Weight (MW)424.87
Molecular FormulaC₂₁H₂₅ClO₇
CAS No.960404-86-8
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3537 mL11.7683 mL23.5366 mL47.0732 mL
5mM0.4707 mL2.3537 mL4.7073 mL9.4146 mL
10mM0.2354 mL1.1768 mL2.3537 mL4.7073 mL
20mM0.1177 mL0.5884 mL1.1768 mL2.3537 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.