Danegaptide (GAP-134) hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $800 | Check With Us |
| 100mg | $1350 | Check With Us |
| 200mg | $2025 | Check With Us |
: Cat #: V21513 CAS #: 943133-81-1 Purity ≥ 99%
Description: Danegaptide hydrochloride (GAP-134 and ZP-1609) is a novel, potent, selective and orally bioavailable small molecule gap-junction modifier with a potential for the treatment of atrial fibrillation.
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| Molecular Weight (MW) | 327.76 |
|---|---|
| Molecular Formula | C14H18ClN3O4 |
| CAS No. | 943133-81-1 |
| SMILES Code | O=C(O)[C@H]1N(C(CN)=O)C[C@H](NC(C2=CC=CC=C2)=O)C1.[H]Cl |
| Protocol | In Vitro | Danegaptide (GAP-134, compound 9f; 0.01 nM-100 μM) Reduces dye uptake in cultured C6 glioma cells in a dose-dependent manner |
|---|---|---|
| In Vivo | Danegaptide (GAP-134, compound 9f) in mouse CaCl2 In the model, the efficacy of oral administration was evaluated after oral administration. For oral doses of 5-20 mg/kg, Danegaptide significantly prolongs the infusion of CaCl in mice2 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0510 mL | 15.2551 mL | 30.5101 mL | 61.0203 mL |
| 5mM | 0.6102 mL | 3.0510 mL | 6.1020 mL | 12.2041 mL |
| 10mM | 0.3051 mL | 1.5255 mL | 3.0510 mL | 6.1020 mL |
| 20mM | 0.1526 mL | 0.7628 mL | 1.5255 mL | 3.0510 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.