Dalpiciclib
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $2000 | Check With Us |
| 100mg | $3300 | Check With Us |
| 200mg | $4950 | Check With Us |
: Cat #: V3317 CAS #: 1637781-04-4 Purity ≥ 99%
Description: Dalpiciclib (also known as SHR-6390) is a novel,highly selective, orally bioavailable CDK4/6 inhibitor with anticancer acivity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 446.54 |
|---|---|
| Molecular Formula | C25H30N6O2 |
| CAS No. | 1637781-04-4 |
| Protocol | In Vitro | Dalpiciclib (0-4 μM, 72 h) inhibits cell proliferation in a dose-dependent manner |
|---|---|---|
| In Vivo | Dalpiciclib (oral gavage; 150 mg/kg; once weekly; 3 weeks) shows antitumor activity against ESCC xenografts | |
| Animal model | NOD/SCID mice (ESCC PDXs models) | |
| Dosages | 150 mg/kg | |
| Administration | Oral gavage; 150 mg/kg; once weekly; 3 weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2394 mL | 11.1972 mL | 22.3944 mL | 44.7888 mL |
| 5mM | 0.4479 mL | 2.2394 mL | 4.4789 mL | 8.9578 mL |
| 10mM | 0.2239 mL | 1.1197 mL | 2.2394 mL | 4.4789 mL |
| 20mM | 0.1120 mL | 0.5599 mL | 1.1197 mL | 2.2394 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.