Dalcetrapib (JTT-705, RO4607381)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $900 | In Stock |
| 200mg | $1350 | In Stock |
| 500mg | $2290 | In Stock |
: Cat #: V0914 CAS #: 211513-37-0 Purity ≥ 98%
Description: Dalcetrapib (formerly JTT-705; RO-4607381; JTT705; RO4607381) is a novel, potent and selective inhibitor of CETP (Cholesteryl ester transfer protein) with the potential to prevent cardiovascular diseases.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 389.59 |
|---|---|
| Molecular Formula | C23H35NO2S |
| CAS No. | 211513-37-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 78 mg/mL (200.2 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 78 mg/mL (200.2 mM) | |
| Solubility In Vivo | 0.5% methylcellulose: 30 mg/mL |
| SMILES Code | CC(C)C(SC1=CC=CC=C1NC(C2(CC(CC)CC)CCCCC2)=O)=O |
| Synonyms | Dalcetrapib; JTT-705; RO-4607381; RO4607381; RO 4607381; JTT705; JTT 705 |
| Protocol | In Vitro | Dalcetrapib (JTT-705) (0.1-10 μM; 21 h) dose-dependently increases pre-β-HDL formatio. |
|---|---|---|
| In Vivo | Dalcetrapib (100 mg/kg; i.g.; twice daily for 7 days) significantly increases fecal elimination of neutral sterols, bile acids, and plasma HDL-cholesterol. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5668 mL | 12.8340 mL | 25.6680 mL | 51.3360 mL |
| 5mM | 0.5134 mL | 2.5668 mL | 5.1336 mL | 10.2672 mL |
| 10mM | 0.2567 mL | 1.2834 mL | 2.5668 mL | 5.1336 mL |
| 20mM | 0.1283 mL | 0.6417 mL | 1.2834 mL | 2.5668 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.