Dabigatran ethyl ester hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $495 | To Be Confirmed |
| 250mg | $945 | To Be Confirmed |
| 500mg | $1420 | To Be Confirmed |
: Cat #: V31684 CAS #: 211914-50-0 Purity ≥ 99%
Description: Dabigatran ethyl ester HCl is the hydrochloride salt of Dabigatran ethyl ester which is the ethyl ester form of dabigatran.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 536.03 |
|---|---|
| Molecular Formula | C27H30ClN7O3 |
| CAS No. | 211914-50-0 |
| Synonyms | Dabigatran ethyl ester hydrochloride |
| Protocol | In Vitro | The Ki of dabigatran (ethyl ester hydrochloride) toward NQO2 is 0.9 μM and the IC50 is 0.8 μM. The ethyl ester group of dabigatran (ethyl ester hydrochloride) significantly extends the interaction surface especially with hydrophobic amino acids such as Ile 128 and Met 154. Dabigatran ethyl ester has higher affinity than Dabigatran to both thrombin and NQO2. |
|---|---|---|
| In Vivo | Dabigatran (Ki=4.5 nM) could bind to human thrombin selectively, and reversibly to realize a strong and long-lasting anticoagulant effect. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8656 mL | 9.3278 mL | 18.6557 mL | 37.3113 mL |
| 5mM | 0.3731 mL | 1.8656 mL | 3.7311 mL | 7.4623 mL |
| 10mM | 0.1866 mL | 0.9328 mL | 1.8656 mL | 3.7311 mL |
| 20mM | 0.0933 mL | 0.4664 mL | 0.9328 mL | 1.8656 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.