Dabigatran (BIBR 953)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $315 | Check With Us |
| 500mg | $470 | Check With Us |
| 1g | $705 | Check With Us |
: Cat #: V1848 CAS #: 211914-51-1 Purity ≥ 98%
Description: Dabigatran (formerly BIBR 953; Pradaxa; Prazaxa; BIBR 953ZW) is a potent, nonpeptide, reversible, selective and direct thrombin inhibitor used to treat blood clots.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 471.51 |
|---|---|
| Molecular Formula | C25H25N7O3 |
| CAS No. | 211914-51-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 0.5 mg/mL (1.06 mM)r |
| Water: N/Ar | |
| Ethanol: < 1 mg/mL | |
| Solubility In Vivo | 10% Trifluoroacetic acid water solution: 33 mg/mL |
| Synonyms | BIBR 953; Pradaxa; BIBR953; BIBR-953; Dabigatran Etexilate; Prazaxa |
| Protocol | In Vitro | Dabigatran (BIBR 953) shows concentration-dependent anticoagulant effects in various species in vitro, doubling the activated partial thromboplastin time (aPTT), prothrombin time (PT) and ecarin clotting time (ECT) in human platelet-poor plasma at concentrations of 0.23, 0.83 and 0.18 μM, respectively. |
|---|---|---|
| In Vivo | Dabigatran (0.01-0.1 mg/kg; i.v.) inhibits clot formation with an ED50 of 0.033 mg/kg in Wessler model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1208 mL | 10.6042 mL | 21.2085 mL | 42.4169 mL |
| 5mM | 0.4242 mL | 2.1208 mL | 4.2417 mL | 8.4834 mL |
| 10mM | 0.2121 mL | 1.0604 mL | 2.1208 mL | 4.2417 mL |
| 20mM | 0.1060 mL | 0.5302 mL | 1.0604 mL | 2.1208 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.