D159687

This product is for research use only, not for human use. We do not sell to patients.

D159687
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$2300To Be Confirmed
200mg$3450To Be Confirmed
500mg$5820To Be Confirmed

Cat #: V19061 CAS #: 1155877-97-6 Purity ≥ 98%

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Molecular Weight (MW)366.84
Molecular FormulaC21H19ClN2O2
CAS No.1155877-97-6
SMILES CodeO=C(N)NC1=CC=C(CC2=CC=C(OC)C(C3=CC=CC(Cl)=C3)=C2)C=C1
SynonymsD159687; D-159687; D 159687;
ProtocolIn VitroD159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM. D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment.
In VivoD159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7260 mL13.6299 mL27.2598 mL54.5197 mL
5mM0.5452 mL2.7260 mL5.4520 mL10.9039 mL
10mM0.2726 mL1.3630 mL2.7260 mL5.4520 mL
20mM0.1363 mL0.6815 mL1.3630 mL2.7260 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.