D159687
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2300 | To Be Confirmed |
| 200mg | $3450 | To Be Confirmed |
| 500mg | $5820 | To Be Confirmed |
: Cat #: V19061 CAS #: 1155877-97-6 Purity ≥ 98%
Description: D159687 is a selective negative allosteric modulator (NAM) of PDE4D.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 366.84 |
|---|---|
| Molecular Formula | C21H19ClN2O2 |
| CAS No. | 1155877-97-6 |
| SMILES Code | O=C(N)NC1=CC=C(CC2=CC=C(OC)C(C3=CC=CC(Cl)=C3)=C2)C=C1 |
| Synonyms | D159687; D-159687; D 159687; |
| Protocol | In Vitro | D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM. D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. |
|---|---|---|
| In Vivo | D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7260 mL | 13.6299 mL | 27.2598 mL | 54.5197 mL |
| 5mM | 0.5452 mL | 2.7260 mL | 5.4520 mL | 10.9039 mL |
| 10mM | 0.2726 mL | 1.3630 mL | 2.7260 mL | 5.4520 mL |
| 20mM | 0.1363 mL | 0.6815 mL | 1.3630 mL | 2.7260 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.