CZC54252 HCl

This product is for research use only, not for human use. We do not sell to patients.

CZC54252 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$720Check With Us
250mg$1250Check With Us
500mg$1875Check With Us

Cat #: V4460 CAS #: 1784253-05-9 Purity ≥ 99%

Description: CZC-54252 HCl (CZC54252) is a novel and potent LRRK2 (leucine-rich repeat kinase 2) inhibitor with a potential for Parkinson's disease (PD).

References: Nigel Ramsden, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.

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Molecular Weight (MW)541.45
Molecular FormulaC22H26Cl2N6O4S
CAS No.1784253-05-9
SMILES CodeCS(=O)(NC1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl)=O.[H]Cl
SynonymsCZC-54252 HCl; CZC-54252 hydrochloride; CZC-54252; CZC 54252; CZC54252;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8469 mL9.2345 mL18.4689 mL36.9379 mL
5mM0.3694 mL1.8469 mL3.6938 mL7.3876 mL
10mM0.1847 mL0.9234 mL1.8469 mL3.6938 mL
20mM0.0923 mL0.4617 mL0.9234 mL1.8469 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.