Cyclosporine H
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1350 | Check With Us |
| 100mg | $1950 | Check With Us |
| 200mg | $2925 | Check With Us |
: Cat #: V2048 CAS #: 83602-39-5 Purity ≥ 98%
Description: Cyclosporin H is a naturally occuring cyclic undecapeptide, acting as a potent TPA/PMA (tumor promoting phorbol ester) inhibitor and a selective inhibitor of formyl peptide receptors (FPR-1) with Ki of 0.1 uM.
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| Molecular Weight (MW) | 1202.61 |
|---|---|
| Molecular Formula | C62H111N11O12 |
| CAS No. | 83602-39-5 |
| Protocol | In Vitro | The cyclic undecapeptide, cyclosporin H, is a potent inhibitor of formyl-Met-Leu-Phe (FMLP)-induced superoxide anion (O2-) formation in human neutrophils. Cyclosporin H inhibits FMLP binding in HL-60 membranes with a Ki of 0.1 μM. Cyclosporin H inhibits activation by FMLP of high affinity GTPase (the enzymatic activity of alpha-subunits of heterotrimeric regulatory guanine nucleotide-binding proteins) in HL-60 membranes with a Ki of 0.79 μM. Cyclosporin H inhibits the stimulatory effects of FMLP on cytosolic Ca2+ concentration ([Ca2+]i), O2- formation, and beta-glucuronidase release with Ki values of 0.08, 0.24, and 0.45 μM, respectively |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.8315 mL | 4.1576 mL | 8.3152 mL | 16.6305 mL |
| 5mM | 0.1663 mL | 0.8315 mL | 1.6630 mL | 3.3261 mL |
| 10mM | 0.0832 mL | 0.4158 mL | 0.8315 mL | 1.6630 mL |
| 20mM | 0.0416 mL | 0.2079 mL | 0.4158 mL | 0.8315 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.