CVT-12012

This product is for research use only, not for human use. We do not sell to patients.

CVT-12012
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$650To Be Confirmed
250mg$1300To Be Confirmed
500mg$1950To Be Confirmed

Cat #: V2687 CAS #: 1018675-35-8 Purity ≥ 98%

Description: CVT-12012 (also known as CVT12012, CVT 12012) is an orally bioavailable stearoyl-coA desaturase (SCD) inhibitor (IC50s = 38 nM, 6.1 nM for rat microsomal and human HEPG2).

References: Koltun DO, et al. Potent, orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4070-4.

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Product Promise

Promise
Molecular Weight (MW)434.41
Molecular FormulaC21H21F3N4O
CAS No.1018675-35-8
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mMr
Water: N/Ar
Ethanol: N/A
SMILES CodeO=C(NCCN1C(C(C)=NC2=C1C=C(NCC3=CC=CC(C(F)(F)F)=C3)C=C2)=O)CO
SynonymsUNII-OH3J29Q653; CVT-12012; CVT 12012; CVT12012
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3020 mL11.5099 mL23.0197 mL46.0395 mL
5mM0.4604 mL2.3020 mL4.6039 mL9.2079 mL
10mM0.2302 mL1.1510 mL2.3020 mL4.6039 mL
20mM0.1151 mL0.5755 mL1.1510 mL2.3020 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.