CPI-268456 | CAS 1380087-86-4

CPI-268456

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1250	Check With Us
200mg	$1875	Check With Us
500mg	$3160	Check With Us

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Cat #: V18762 CAS #: 1380087-86-4 Purity ≥ 98%

Description: CPI-268456 is an inhibitor of bromodomain-containing protein 4 (BRD4), binding to BRD4 (IC50 =<0.5 µM in a cell-free assay) and inhibiting LPS-induced IL-6 secretion in THP-1 cells (IC50 = <0.5 µM).

References: Brian K. Albrecht, et al. Bromodomain inhibitors and uses thereof. WO2012075383A2.

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Quality Control Documentation

Molecular Weight (MW)	400.26
Molecular Formula	C20H15Cl2N3O2
CAS No.	1380087-86-4
SMILES Code	O=C(N)C[C@@H]1C(ON=C2C)=C2C3=CC=C(Cl)C=C3C(C4=CC=C(Cl)C=C4)=N1
Synonyms	CPI-268456

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4984 mL	12.4919 mL	24.9838 mL	49.9675 mL
5mM	0.4997 mL	2.4984 mL	4.9968 mL	9.9935 mL
10mM	0.2498 mL	1.2492 mL	2.4984 mL	4.9968 mL
20mM	0.1249 mL	0.6246 mL	1.2492 mL	2.4984 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.