CORM-3

This product is for research use only, not for human use. We do not sell to patients.

CORM-3
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
25mg$100In Stock
50mg$150In Stock
100mg$220In Stock
250mg$370In Stock

Cat #: V1935 CAS #: 475473-26-8 Purity ≥ 99%

Description: CORM-3 is a water-soluble carbon monoxide (CO)-releasing molecule with potent anti-inflammatory and cardioprotective activity by attenuatingNF-κB p65 nuclear translocation, reducing ROS generation and enhancing intracellular glutathione and superoxide dismutase levels. CORM-3, a CO-releasing molecule, can activate the soluble guanylyl cyclase to mimic the anti-allergic and anti-anaphylactic effects of heme oxygenase. According to reports, CORM-3 has an impact on cardiovascular inflammation. It lessens the in vitro model's induction of CD54 expression on EC by PMN. Both in vitro and in vivo, CORM-3 has vasoactive qualities. By controlling blood pressure and vessel tone, it exhibits significant vasodilatation.

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Molecular Weight (MW)294.61
Molecular FormulaC5H4ClNO5Ru
CAS No.475473-26-8
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsCORM-3; CORM3; CORM 3
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3943 mL16.9716 mL33.9432 mL67.8864 mL
5mM0.6789 mL3.3943 mL6.7886 mL13.5773 mL
10mM0.3394 mL1.6972 mL3.3943 mL6.7886 mL
20mM0.1697 mL0.8486 mL1.6972 mL3.3943 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.