Cobimetinib hemifumarate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $960 | Check With Us |
| 500mg | $1350 | Check With Us |
| 1g | $2025 | Check With Us |
: Cat #: V4524 CAS #: 1369665-02-0 Purity ≥ 98%
Description: Cobimetinib hemifumarate (formerly also known as RG7420; XL518; GDC0973), the hemifumarate salt of cobimetinib, is an oral, highly potent and selective MEK1 inhibitor with potential antineoplastic activity.
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| Molecular Weight (MW) | 647.38 |
|---|---|
| Molecular Formula | C₂₅H₂₅F₃IN₃O₆ |
| CAS No. | 1369665-02-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: 47 mg/mL | |
| Solubility In Vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O: 5 mg/mL |
| SMILES Code | O=C(/C=C/C(O)=O)O.O=C(N1CC(O)(C1)[C@H]2NCCCC2)C3=CC=C(C(F)=C3NC4=CC=C(C=C4F)I)F.O=C(N5CC(O)(C5)[C@H]6NCCCC6)C7=CC=C(C(F)=C7NC8=CC=C(C=C8F)I)F |
| Synonyms | XL518 hemifumarate, GDC-0973, RG7420 fumarate; XL518; XL 518; XL-518 fumarate; GDC0973 fumarate; GDC 0973; GDC-0973; RG-7420; RG 7420 fumarate |
| Protocol | In Vitro | The EC50 values of Cobimetinib (GDC-0973) for 888MEL and A2058 cells are 0.2 μM, 10 μM, respectivelly. Melanoma cells are treated with EC50 concentration of MEK and PI3K inhibitors for 24 hours (888MEL: 0.05 μM GDC-0973, 2.5 μM GDC-0941; A2058: 2.5 μM GDC-0973, 2.5 μM GDC-0941). |
|---|---|---|
| In Vivo | In the NCI-H2122 KRASG12C mutant non-small cell lung carcinoma (NSCLC) xenograft model, treatment with up to 5 mg/kg Cobimetinib (GDC-0973) lead to moderate TGI and at 10 mg/kg approaches tumor stasis. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5447 mL | 7.7234 mL | 15.4469 mL | 30.8938 mL |
| 5mM | 0.3089 mL | 1.5447 mL | 3.0894 mL | 6.1788 mL |
| 10mM | 0.1545 mL | 0.7723 mL | 1.5447 mL | 3.0894 mL |
| 20mM | 0.0772 mL | 0.3862 mL | 0.7723 mL | 1.5447 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.