Cobicistat (GS9350)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1020 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V0815 CAS #: 1004316-88-4 Purity ≥ 98%
Description: Cobicistat (trade name Tybost; Genvoya; GS-9350; GS 9350) is a novel, potent and selective inhibitor of CYP3A (cytochrome P450 3A) with IC50 of 30-285 nM.
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- Related Biological Data
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| Molecular Weight (MW) | 776.02 |
|---|---|
| Molecular Formula | C40H53N7O5S2 |
| CAS No. | 1004316-88-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (128.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 100 mg/mL (128.9 mM) | |
| Solubility In Vivo | 5% DMSO+40% PEG 300+ddH2O: 30mg/mL |
| SMILES Code | O=C(OCC1=CN=CS1)N[C@H](CC[C@@H](NC([C@@H](NC(N(CC2=CSC(C(C)C)=N2)C)=O)CCN3CCOCC3)=O)CC4=CC=CC=C4)CC5=CC=CC=C5 |
| Synonyms | Cobicistat; GS9350; trade name: Tybost; Genvoya; GS-9350; GS 9350; |
| Protocol | In Vitro | In the glucose uptake assay with mouse adipocytes, Ritonavir shows a pronounced effect at the concentration of 10 μM. In contrast, the effects on glucose uptake by Cobicistat (10 μM) is significantly less. The minimal adverse effects of Cobicistat in these assays suggest a lower potential for toxicity related to altered lipid metabolism. In the lipid accumulation assay with the human adipocytes, Ritonavir shows a clear effect with an EC50 of 16 μM. However, Cobicistat exhibits no effect at a concentration up to 30 μM. The mode of inhibition of human CYP3A by Cobicistat and Ritonavir shares the same mechanism of action for the inhibition of CYP3A. It shows its inhibitory effects on CYP3A may involve directly at the heme group of the CYP3A enzyme. In HIV-1 protease enzymatic assay and antiviral cellular assays. Cobicistat is inactive against HIV-1 protease (IC50>30 μM) . And Cobicistat has no inhibitory effect against HIV replication in a multicycle 5-day MT-2 HIV infection assay (EC50>30 μM). In assays using MT-2 cells, Cobicistat exhibits minimal cytotoxicity, with a CC50 value above 80 μM. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.2886 mL | 6.4431 mL | 12.8863 mL | 25.7725 mL |
| 5mM | 0.2577 mL | 1.2886 mL | 2.5773 mL | 5.1545 mL |
| 10mM | 0.1289 mL | 0.6443 mL | 1.2886 mL | 2.5773 mL |
| 20mM | 0.0644 mL | 0.3222 mL | 0.6443 mL | 1.2886 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
=
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This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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C2
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V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.