Home > Signaling Pathways>Transmembrane>CRAC Channel>CM-4620
CM-4620

This product is for research use only, not for human use. We do not sell to patients.

CM-4620
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$2350Check With Us
500mg$3850Check With Us
1g$5780Check With Us
email: [email protected]        [email protected]

Cat #: V32322 CAS #: 1713240-67-5 Purity ≥ 99%

Description: CM4620 (CM-4620) is a novel, potent and selective calcium-release activated calcium-channel (CRAC) inhibitor with antiinflammatory effects.

References: ARYL SULFONOHYDRAZIDES. WO2016/138472Al.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)421.76
Molecular FormulaC₁₉H₁₁ClF₃N₃O₃
CAS No.1713240-67-5
SMILES Code O=C(NC1=NC=C(C2=C(Cl)C=C(OC(F)(F)O3)C3=C2)N=C1)C4=C(C)C=CC=C4F
Synonyms CM-4620; CM 4620; CM4620
ProtocolIn VitroZegocractin (compound 1) has been determined to inhibit ICs in the Orai 1/STIM1 channel50 is a 119 nM IC that rejects Orai2/STIM1 channels50 is 895 nM. It is more efficient on Orai1 than Orai2-type CRAC channels. In human PBMCs, zegocractin potently inhibits the release of multiple cytokines (ICs) that play an important role in T cells50，IFN γ：138 nM，IL-4：879 nM，IL-6：135 nM，IL-1β：240 nM，IL-10：303 nM，TNFα：225 nM，IL-2：59 nM，IL-17 120 nM)
In VivoMouse PACs were treated with the CRAC inhibitor Zegocractin or GSK-7975A and their calcium uptake was monitored. After treatment with a 700 nM inhibitor, both CRAC inhibitors reduced the rate of calcium depot-manipulated calcium into the ER to 50% of the control level. Zegocractin blocks 10% reuptake at 100 mM
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3710 mL11.8551 mL23.7102 mL47.4203 mL
5mM0.4742 mL2.3710 mL4.7420 mL9.4841 mL
10mM0.2371 mL1.1855 mL2.3710 mL4.7420 mL
20mM0.1186 mL0.5928 mL1.1855 mL2.3710 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.