Clozapine N-oxide diHCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $400 | To Be Confirmed |
| 250mg | $750 | To Be Confirmed |
| 500mg | $1125 | To Be Confirmed |
: Cat #: V38749 CAS #: 2250025-93-3 Purity ≥ 99%
Description: Clozapine N-oxide diHCl is a major metabolite of Clozapine which is an antipsychotic acting as an antagonist of dopamine and other receptors such as muscarinic M1 receptor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 415.74 |
|---|---|
| Molecular Formula | C18H21Cl3N4Or |
| CAS No. | 2250025-93-3 |
| Protocol | In Vitro | Clozapine N-oxide (CNO) binds to non-DREADD receptors at concentrations required for DREADD activation and is metabolized in reverse to its parent compound, clozapine, an atypical antipsychotic that acts on a variety of pharmacological targets and produces multiple physiological and behavioral effects |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4053 mL | 12.0267 mL | 24.0535 mL | 48.1070 mL |
| 5mM | 0.4811 mL | 2.4053 mL | 4.8107 mL | 9.6214 mL |
| 10mM | 0.2405 mL | 1.2027 mL | 2.4053 mL | 4.8107 mL |
| 20mM | 0.1203 mL | 0.6013 mL | 1.2027 mL | 2.4053 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.