This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 1g | $290 | Check With Us |
| 2g | $520 | Check With Us |
| 5g | $875 | Check With Us |
: Cat #: V2096 CAS #: 60200-06-8 Purity ≥ 98%
Description: Clorsulon (also known as L631529; MK401) is an antihelminthic agent that is used in the treatment of Fasciola hepatica infections in calves and sheep. Clorsulon acts as a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep.
References: [1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7.
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| Molecular Weight (MW) | 380.66 |
|---|---|
| Molecular Formula | C8H8Cl3N3O4S2 |
| CAS No. | 60200-06-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 76 mg/mL (199.7 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 7 mg/mL (18.4 mM) | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL |
| Synonyms | MK 401; MK-401; MK401; L-631529; L631529; L 631529; L-631,529; L631,529; L 631,529; Clorsulone; Clorsulonum; BRN 2821757; BRN2821757; BRN-2821757 |
| Protocol | In Vitro | In vitro activity: Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep. Target: Antiparasitic Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. |
|---|---|---|
| In Vivo | Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation. | |
| Animal model | Rat |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6270 mL | 13.1351 mL | 26.2702 mL | 52.5403 mL |
| 5mM | 0.5254 mL | 2.6270 mL | 5.2540 mL | 10.5081 mL |
| 10mM | 0.2627 mL | 1.3135 mL | 2.6270 mL | 5.2540 mL |
| 20mM | 0.1314 mL | 0.6568 mL | 1.3135 mL | 2.6270 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.