Clopidogrel thiolactone
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1750 | Check With Us |
| 250mg | $2750 | Check With Us |
| 500mg | $4125 | Check With Us |
: Cat #: V3330 CAS #: 1147350-75-1 Purity ≥ 98%
Description: Clopidogrel thiolactone (also known as 2-Oxoclopidogrel) is a metabolite of Clopidogrel which is a P2Y12 receptor inhibitor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 337.82 |
|---|---|
| Molecular Formula | C16H16ClNO3S |
| CAS No. | 1147350-75-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(OC)[C@H](C1=CC=CC=C1Cl)N2CCC3C(C2)=CC(S3)=O |
| Synonyms | 2-Oxo-clopidogrel; 2-Oxoclopidogrel; 2-Oxo clopidogrel |
| Protocol | In Vivo | Clopidogrel thiolactone (8 μm/kg; i.v.; Sprague-Dawley male rats) has good biological availability and pharmacokinetic parameters |
|---|---|---|
| Animal model | Sprague-Dawley male rats | |
| Dosages | 8 μm/kg; orally clopidogrel (24 μm/kg) | |
| Administration | Intravenous injection; collected blood at 0 h (before dosing) and 0.083, 0.167, 0.5, 1, 2, 4, 6, 8, 24 h postdose. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9602 mL | 14.8008 mL | 29.6016 mL | 59.2031 mL |
| 5mM | 0.5920 mL | 2.9602 mL | 5.9203 mL | 11.8406 mL |
| 10mM | 0.2960 mL | 1.4801 mL | 2.9602 mL | 5.9203 mL |
| 20mM | 0.1480 mL | 0.7400 mL | 1.4801 mL | 2.9602 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.