CL2-SN-38 | CAS 1036969-20-6

CL2-SN-38

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1800	Check With Us
500mg	$3000	Check With Us
1g	$4500	Check With Us

: [email protected] [email protected]

Cat #: V34086 CAS #: 1036969-20-6 Purity ≥ 99%

Description: CL2-SN-38 is a cleavable linker-drug conjugate used for the synthesis of antibody drug conjugates (ADC). As a part of the antibody drug conjugate (ADC), it can conjugate with the anti-Trop-2-humanized antibody hRS7. The anti-Trop-2 hRS7-CL2A-SN-38 ADC exhibits potent and highly specific anticancer effects against a range of human solid tumor types. Reference: Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69

References: [1]. Cardillo TM, et al. Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys. Clin Cancer Res. 2011 May 15;17(10):3157-69

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1627.79
Molecular Formula	C82H106N12O23
CAS No.	1036969-20-6
Solubility In Vitro	DMSO : 100 mg/mL (61.43 mM; Need ultrasonic)
SMILES Code	O=C(OCC1=C2C=C3C4=NC5=CC=C(C=C5C(CC)=C4CN3C1=O)O)[C@]2(OC(OCC6=CC=C(C=C6)NC([C@@H](NC([C@H](CC7=CC=CC=C7)NC(COCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCN8C=C(N=N8)CNC(C9CCC(CC9)CN%10C(C=CC%10=O)=O)=O)=O)=O)=O)CCCCN)=O)=O)CC.O=C(O)C(Cl)Cl.O=C(O)C(Cl)Cl
Synonyms	CL2-SN-38 2,2-dichloro-acetic acid; CL2-SN-38 DCA; CL2-SN 38; CL2-SN-38; CL2-SN38;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.6143 mL	3.0716 mL	6.1433 mL	12.2866 mL
5mM	0.1229 mL	0.6143 mL	1.2287 mL	2.4573 mL
10mM	0.0614 mL	0.3072 mL	0.6143 mL	1.2287 mL
20mM	0.0307 mL	0.1536 mL	0.3072 mL	0.6143 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.