Cl-amidine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1300 | Check With Us |
| 500mg | $1900 | Check With Us |
| 1g | $2850 | Check With Us |
: Cat #: V28803 CAS #: 913723-61-2 Purity ≥ 99%
Description: Cl-amidine is a novel and potent Amyloid-β production inhibitor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 310.78 |
|---|---|
| Molecular Formula | C14H19ClN4O2 |
| CAS No. | 913723-61-2 |
| Synonyms | Cl-amidine |
| Protocol | In Vitro | Cl-amidine is a bioavailable haloacetamidine-based compound that inhibits all the active PAD isozymes with near equal potency (kinact/KI=13,000 M-1•min-1 for PAD4). |
|---|---|---|
| In Vivo | Cl-amidine (75 mg/kg, ip once daily) suppresses and treats DSS-induced colitis in mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2177 mL | 16.0886 mL | 32.1771 mL | 64.3542 mL |
| 5mM | 0.6435 mL | 3.2177 mL | 6.4354 mL | 12.8708 mL |
| 10mM | 0.3218 mL | 1.6089 mL | 3.2177 mL | 6.4354 mL |
| 20mM | 0.1609 mL | 0.8044 mL | 1.6089 mL | 3.2177 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.