cis-Lomibuvir

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V49317 CAS #: 1026785-59-0 Purity ≥ 99%

Description: cis-Lomibuvir (cis-VX-222) is the cis-enantiomer of Lomibuvir (VX222; VCH-222), which is a selective, non-nucleoside polymerase inhibitor with antiviral activity. It acts by targeting thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.

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Molecular Weight (MW)	445.61
Molecular Formula	C25H35NO4S
CAS No.	1026785-59-0

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2441 mL	11.2206 mL	22.4411 mL	44.8823 mL
5mM	0.4488 mL	2.2441 mL	4.4882 mL	8.9765 mL
10mM	0.2244 mL	1.1221 mL	2.2441 mL	4.4882 mL
20mM	0.1122 mL	0.5610 mL	1.1221 mL	2.2441 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.