Cilostamide (OPC3689)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1200 | Check With Us |
| 200mg | $1800 | Check With Us |
| 500mg | $3035 | Check With Us |
: Cat #: V18334 CAS #: 68550-75-4 Purity ≥ 98%
Description: Cilostamide (OPC3689) is a potent and highly selective inhibitor of type III phosphodiesterase (PDE3) (IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively), it has antithrombotic and anti-intimal hyperplastic activity.
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| Molecular Weight (MW) | 342.43 |
|---|---|
| Molecular Formula | C20H26N2O3 |
| CAS No. | 68550-75-4 |
| SMILES Code | O=C(N(C1CCCCC1)C)CCCOC2=CC3=C(NC(C=C3)=O)C=C2 |
| Synonyms | Cilostamide; OPC 3689; OPC-3689; OPC3689; |
| Protocol | In Vitro | Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity. Cilostamide weakly inhibits PDE2, PDE4, PDE5, PDE7, and PDE1, with IC50s of 12.5, 88.8, 15.2, 22.0 and > 300 μM, respectively. Cilostamide potently inhibits thrombin-induced platelet aggregation (IC50, 1.1 μM). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9203 mL | 14.6015 mL | 29.2030 mL | 58.4061 mL |
| 5mM | 0.5841 mL | 2.9203 mL | 5.8406 mL | 11.6812 mL |
| 10mM | 0.2920 mL | 1.4602 mL | 2.9203 mL | 5.8406 mL |
| 20mM | 0.1460 mL | 0.7301 mL | 1.4602 mL | 2.9203 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.