Ciforadenant (CPI-444; V81444)

This product is for research use only, not for human use. We do not sell to patients.

Ciforadenant (CPI-444; V81444)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$1103-6 Days
10mg$1803-6 Days
25mg$2903-6 Days
50mg$4403-6 Days
100mg$6203-6 Days
250mg$9103-6 Days
500mg$12903-6 Days
email: [email protected]        [email protected]

Cat #: V3272 CAS #: 1202402-40-1 Purity ≥ 99%

Description: Ciforadenant (formerly known as CPI-444; V-81444) is a potent, selective and orally bioactive small molecule inhibitor of the adenosine-A2a receptor (A2AR) on T-lymphocytes with anticancer and immunomodulatory activities and the potential to be used in cancer immunotherapy . Ciforadenant is presently being tested against a variety of solid tumors in a Phase I clinical trial both as a single agent and in conjunction with the PD-L1 inhibitor atezolizumab. It is possible to elicit antitumor responses with ciporadenant. When taken orally, ciporadenant binds to adenosine A2A receptors expressed on the surface of immune cells, such as DCs, T-lymphocytes, macrophages, and natural killer (NK) cells. This stops tumor-released adenosine from interacting with these important immune surveillance cells' A2A receptors, thereby reversing the immunosuppressive effects of adenosine in the tumor microenvironment.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)407.43
Molecular FormulaC20H21N7O3
CAS No.1202402-40-1
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsCiforadenant; CPI-444; V81444; CPI 444; V-81444; CPI444; V 81444
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4544 mL12.2720 mL24.5441 mL49.0882 mL
5mM0.4909 mL2.4544 mL4.9088 mL9.8176 mL
10mM0.2454 mL1.2272 mL2.4544 mL4.9088 mL
20mM0.1227 mL0.6136 mL1.2272 mL2.4544 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.