Chloramphenicol
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $350 | Check With Us |
| 100g | $500 | Check With Us |
| 200mg | $750 | Check With Us |
: Cat #: V18163 CAS #: 56-75-7 Purity ≥ 99%
Description: Chloramphenicol (Globenicol; Chlorocid; Detreomycin; Levomycetin) is a bacteriostatic antibiotic agent with a broad-spectrum activity against a wide range of gram-positive and gram-negative organisms.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 323.13 |
|---|---|
| Molecular Formula | C11H12Cl2N2O5 |
| CAS No. | 56-75-7 |
| SMILES Code | C1=CC(=CC=C1C(C(CO)NC(=O)C(Cl)Cl)O)[N+](=O)[O-] |
| Synonyms | Globenicol; Detreomycin; Kloramfenikol; Levomycetin; Ophthochlor; Syntomycin; Chloramphenicol; Chlornitromycin; Chloromycetin; Levomycetin; Chlorocid |
| Protocol | In Vitro | Chloramphenicol (100 μg/mL, 0-24 h) induces autophagy in NSCLC cells, substantially increases the levels of autophagic biomarkers (beclin-1, Atg12-Atg5 conjugates, and LC3-II). Chloramphenicol (1-100 μg/mL, 18-24 h) inhibits the HIF-1α pathway in NSCLC cells in a concentration-dependent manner. |
|---|---|---|
| In Vivo | Chloramphenicol (0-3500 mg/kg, Gavage, daily, for 5 days) decreases erythrocytes and erythrocyte precursors and reduces marrow erythroid cells were at day 1 post-dosing, and returns to normal by 14 days post-dosing. | |
| Animal model | Female B6C3F1 mice (12-14 weeks old) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0947 mL | 15.4736 mL | 30.9473 mL | 61.8946 mL |
| 5mM | 0.6189 mL | 3.0947 mL | 6.1895 mL | 12.3789 mL |
| 10mM | 0.3095 mL | 1.5474 mL | 3.0947 mL | 6.1895 mL |
| 20mM | 0.1547 mL | 0.7737 mL | 1.5474 mL | 3.0947 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.