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| Size | Price | Stock |
|---|---|---|
| 10mg | $100 | 3-6 Days |
| 25mg | $170 | 3-6 Days |
| 50mg | $260 | 3-6 Days |
| 100mg | $360 | 3-6 Days |
| 250mg | $530 | 3-6 Days |
: Cat #: V3843 CAS #: 1616493-44-7 Purity ≥ 99%
Description: Chidamide (CS-055, Tucidinostat, HBI-8000; trade name: Epidaza), is a potent and orally bioavailable benzamide-type histone deacetylase (HDAC) inhibitor with IC50s of 95, 160, 67 and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10, respectively. Chidamide is classified as an orphan drug in Japan and is approved by the Chinese FDA for the treatment of relapsed or refractory peripheral T-cell lymphoma (PTCL). It's only legal in China as of April 2015. The selective binding and inhibition of HDAC by chindamide causes the histone protein H3 to become more acetylated. Additionally, it suppresses the expression of signaling kinases in the MAPK/Ras and PI3K/Akt signaling pathways. In addition, it may cause cell cycle arrest and induce tumor cell apoptosis, which may stop the growth of tumor cells in tumor cells that are vulnerable to it. Research is being done on chidamide as a potential pancreatic cancer treatment. It is not, however, approved by the US FDA for the treatment of pancreatic cancer.
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| Molecular Weight (MW) | 390.41 |
|---|---|
| Molecular Formula | C22H19FN4O2 |
| CAS No. | 1616493-44-7 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | HBI8000; HBI 8000; HBI-8000; CS055; CS-055; CS 055; Chidamide; Tucidinostat |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5614 mL | 12.8070 mL | 25.6141 mL | 51.2282 mL |
| 5mM | 0.5123 mL | 2.5614 mL | 5.1228 mL | 10.2456 mL |
| 10mM | 0.2561 mL | 1.2807 mL | 2.5614 mL | 5.1228 mL |
| 20mM | 0.1281 mL | 0.6404 mL | 1.2807 mL | 2.5614 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.