Description: Chetomin (also called NSC289491, BRN0077366), an antibiotic metabolite of chaetomium cochliodes and a natural product isolated from Chaetomium species which has anticancer, antibacterial and antifungal properties, is an inhibitor of HIF-1 which weakens transcription of HIF-1, and disrupts the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations. Chetomin may find application as a chemotherapeutic agent for cancer treatment. Chetomin specifically inhibits HIF-1 activities by interfering with HIF-1's interaction with p300, a transcriptional coactivator. In vitro, chetomin-induced HIF-1 inhibition significantly lowers hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells. Additionally, chemomin causes XIAP to break down and increases TRAIL sensitivity in urogenital cancer cells.