CH-223191
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
Size | Price | Stock |
---|---|---|
250mg | $860 | Check With Us |
500mg | $1350 | Check With Us |
1g | $2025 | Check With Us |
Cat #: V0952 CAS #: 301326-22-7 Purity ≥ 99%
Description: CH-223191 (CH 223191; CH223191) is a potent and specific/selective aryl hydrocarbon receptor (AhR) antagonist with important biological activity.
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Molecular Weight (MW) | 333.39 |
---|---|
Molecular Formula | C19H19N5O |
CAS No. | 301326-22-7 |
Storage | -20℃ for 3 years in powder formr |
-80℃ for 2 years in solvent | |
Solubility In Vitro | DMSO: 66 mg/mL (198.0 mM)r |
Water: <1 mg/mLr | |
Ethanol: 4 mg/mL (12.0 mM) | |
SMILES Code | O=C(C1=CC=NN1C)NC2=CC=C(/N=N/C3=CC=CC=C3C)C=C2C |
Synonyms | CH223191; CH-223191; CH 223191. |
Protocol | In Vitro | CH-223191 (0.1-10 μM; pre-treated 1 hour) causes a concentration-dependent inhibition of TCDD-induced cytochrome P450 enzyme activity. CH-223191 (0.1-10 μM; pre-treated 1 hour) inhibits TCDD-caused cytochrome P450 1A1 mRNA expression in a in dose-dependent manner. |
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In Vivo | CH-223191 (10 mg/kg; once a day; 25 days) suppresses cytochrome P450 1A1 expression and the intrahepatocyte fat content in liver, reduces activity of AST and ALT in TCDD-treated mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.9995 mL | 14.9975 mL | 29.9949 mL | 59.9898 mL |
5mM | 0.5999 mL | 2.9995 mL | 5.9990 mL | 11.9980 mL |
10mM | 0.2999 mL | 1.4997 mL | 2.9995 mL | 5.9990 mL |
20mM | 0.1500 mL | 0.7499 mL | 1.4997 mL | 2.9995 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.