CGS 21680 HCl

This product is for research use only, not for human use. We do not sell to patients.

CGS 21680 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1650Check With Us
500mg$2650Check With Us
1g$3975Check With Us

Cat #: V1482 CAS #: 124431-80-7 Purity ≥ 98%

Description: CGS 21680 HCl (CGS21680; CGS-21680), the hydrochloride salt of CGS 21680, is a potent and specific agonist of adenosine A2 receptors with potential antideppressant activity.

References: Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38(3):969-75.

Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products

Product Promise

Promise
Molecular Weight (MW)535.98
Molecular FormulaC23H29N7O6.HCl
CAS No.124431-80-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 107 mg/mL (199.6 mM)r
Water: <1 mg/mLr
Ethanol: <1 mg/mL
Solubility In Vivo30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
SynonymsCGS21680; CGS-21680; CGS 21680; CGS-21680 HCl
ProtocolIn VitroCGS21680 significantly upregulates CD39 and CD73 expression. CGS21680 accelerates the adenosine triphosphate (ATP) hydrolysis and adenosine generation
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8657 mL9.3287 mL18.6574 mL37.3148 mL
5mM0.3731 mL1.8657 mL3.7315 mL7.4630 mL
10mM0.1866 mL0.9329 mL1.8657 mL3.7315 mL
20mM0.0933 mL0.4664 mL0.9329 mL1.8657 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.