CGP53353 | CAS 145915-60-2

CGP53353

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
5mg	$180	To Be Confirmed
10mg	$290	To Be Confirmed

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Cat #: V18061 CAS #: 145915-60-2 Purity ≥ 99%

Description: CGP-53353 (DAPH-7) is a potent PKC inhibitor (antagonist) with IC50s of 0.41 μM and 3.8 μM for PKCβII and PKCβI, respectively. CGP-53353 can inhibit glucose-induced cell growth/proliferation and DNA synthesis in AoSMC and A10 cells. CGP-53353 may be utilized to study atherosclerosis in patients with diabetes.

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Physicochemical and Storage Information
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Stock Solution Preparation
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Molecular Weight (MW)	365.34
Molecular Formula	C20H13F2N3O2
CAS No.	145915-60-2
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Synonyms	CGP-53353; CGP 53353; CGP53353

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7372 mL	13.6859 mL	27.3718 mL	54.7435 mL
5mM	0.5474 mL	2.7372 mL	5.4744 mL	10.9487 mL
10mM	0.2737 mL	1.3686 mL	2.7372 mL	5.4744 mL
20mM	0.1369 mL	0.6843 mL	1.3686 mL	2.7372 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.