CFTRinh-172 | CAS 307510-92-5

CFTRinh-172

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$930	Check With Us
500mg	$1399	Check With Us
1g	$2100	Check With Us

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Cat #: V1693 CAS #: 307510-92-5 Purity ≥ 98%

Description: CFTRinh-172 (also known as CFTR Inhibitor172; CFTR-Inh 172; CFTR inhibitor 172) is a potent, voltage-independent, and selective inhibitor of CFTR (Cystic fibrosis transmembrane conductance regulator) with potential anti-fibrotic and anti-diarrhea effects.

References: Ma T, et al. Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion. J Clin Invest. 2002 Dec;110(11):1651-8.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	409.4
Molecular Formula	C18H10F3NO3S2
CAS No.	307510-92-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 82 mg/mL (200.3 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	CFTR inhibitor 172; CFTR Inh-172; CFTR Inhibitor172; CFTR Inh 172; CFTR Inh172; CFTR(Inh)-172; CFTR(Inh)172; CFTR Inhibitor-172;

Protocol	In Vitro	Inhibition of CFTR(inh)-172 occurs at approximately 10 minutes (t1/2=4 min) and within t1/2 It takes about 5 minutes to reverse. CFTRinh-172 at concentrations up to 100 μM
Protocol	In Vivo	A single intraperitoneal injection of CFTR(inh)-172 (250 μg/kg) in mice reduced cholera toxin-induced small intestinal fluid secretion by more than 6% within 90 hours. CFTR(inh)-172 is non-toxic at high concentrations in mouse models. CFTRinh-172 significantly reduces fluid secretion into the saline control circuit, while inactive CFTRinh-172 analogues do not inhibit fluid secretion

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4426 mL	12.2130 mL	24.4260 mL	48.8520 mL
5mM	0.4885 mL	2.4426 mL	4.8852 mL	9.7704 mL
10mM	0.2443 mL	1.2213 mL	2.4426 mL	4.8852 mL
20mM	0.1221 mL	0.6106 mL	1.2213 mL	2.4426 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.