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| Size | Price | Stock |
|---|---|---|
| 1mg | $130 | 3-6 Days |
| 5mg | $300 | 3-6 Days |
| 10mg | $410 | 3-6 Days |
: Cat #: V41394 CAS #: 2244987-03-7 Purity ≥ 99%
Description: CDK12-IN-2 is a highly efficient and selective nanomolar CDK12 inhibitor (IC50=52 nM) with good physical and chemical properties. CDK12-IN-2 is also a strong inhibitor of CDK13, as CDK13 is the closest homolog of CDK12. CDK12-IN-2 has higher kinase selectivity for CDK12 than CDK2, 9, 8 and 7. CDK12-IN-2 inhibits C-terminal Ser2 phosphorylation of RNA polymerase II. CDK12-IN-2 can be used as a good chemical probe for functional studies of CDK12.
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| Molecular Weight (MW) | 532.635486602783 |
|---|---|
| Molecular Formula | C32H32N6O2 |
| CAS No. | 2244987-03-7 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8775 mL | 9.3873 mL | 18.7746 mL | 37.5491 mL |
| 5mM | 0.3755 mL | 1.8775 mL | 3.7549 mL | 7.5098 mL |
| 10mM | 0.1877 mL | 0.9387 mL | 1.8775 mL | 3.7549 mL |
| 20mM | 0.0939 mL | 0.4694 mL | 0.9387 mL | 1.8775 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.