CCT251236
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1600 | To Be Confirmed |
| 100mg | $2350 | To Be Confirmed |
| 200mg | $3525 | To Be Confirmed |
: Cat #: V17743 CAS #: 1693731-40-6 Purity ≥ 98%
Description: CCT-251236, a chemical probe bisamide, is a novel, potent and orally bioavailable Pirin Ligand identified from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen (IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 552.62 |
|---|---|
| Molecular Formula | C32H32N4O5 |
| CAS No. | 1693731-40-6 |
| Protocol | In Vivo | CCT251236 (oral adminstation; 5 or 20 mg/kg) in nontumor bearing immunocompetent BALB/c mice exhibits free Cav0-24h value of 2.0 nM and 1.2 nM, respectively |
|---|---|---|
| Animal model | Athymic mice with SK-OV-3 cells | |
| Dosages | 20 mg/kg; 33 days | |
| Administration | Oral adminstation |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8096 mL | 9.0478 mL | 18.0956 mL | 36.1912 mL |
| 5mM | 0.3619 mL | 1.8096 mL | 3.6191 mL | 7.2382 mL |
| 10mM | 0.1810 mL | 0.9048 mL | 1.8096 mL | 3.6191 mL |
| 20mM | 0.0905 mL | 0.4524 mL | 0.9048 mL | 1.8096 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.