Capmatinib 2HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$240	In Stock
1g	$420	In Stock
5g	$1065	In Stock

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Cat #: V2685 CAS #: 1197376-85-4 Purity ≥ 98%

Description: Capmatinib 2HCl (INCB28060; INC-280; Tabrecta), the dihydrochloride salt of Capmatinib, is an orally bioavailable and ATP-competitive inhibitor of c-MET approved by FDA on August 10, 2022 by the US FDA for adult patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have a mutation leading to mesenchymal-epithelial transition (MET) exon 14 skipping, as detected by an FDA-approved test.

References: Dogan-Topal B, et al. Quantification of FGFR4 inhibitor BLU-554 in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 15;1110-1111:116-123.

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Molecular Weight (MW)	503.38
Molecular Formula	C24H24Cl2N4O4
CAS No.	1197376-85-4
Synonyms	NCB28060 2HCl; INC-280 2HCl; Capmatinib 2HCl;INCB28060 2HCl; INC-280 2HCl; NVP INC280 2HCl; NVP INC-280 2HCl;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9866 mL	9.9329 mL	19.8657 mL	39.7314 mL
5mM	0.3973 mL	1.9866 mL	3.9731 mL	7.9463 mL
10mM	0.1987 mL	0.9933 mL	1.9866 mL	3.9731 mL
20mM	0.0993 mL	0.4966 mL	0.9933 mL	1.9866 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.