Caerulomycin A

This product is for research use only, not for human use. We do not sell to patients.

Caerulomycin A
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
2mg$5103-6 Days
5mg$8503-6 Days
10mg$13903-6 Days
25mg$22603-6 Days
email: sales@invivochem.com        sales@invivochem.cn

Cat #: V4052 CAS #: 21802-37-9 Purity ≥ 99%

Description: Caerulomycin A (also known as Cerulomycin, CaeA) is a novel bipyridyl compound that induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. It is also a toxin that inhibits growth of Entamoeba. It has antifungal and antibiotic activity, and can be used in autoimmune diseases. Cytokines play a very important role in the regulation of immune homeostasis. Regulatory T cells (Tregs) responsible for the generation of peripheral tolerance are under the tight regulation of the cytokine milieu. It was observed that Caerulomycin A substantially up-regulated the pool of Tregs, as evidenced by an increased frequency of CD4(+) Foxp3(+) cells. In addition, CaeA significantly suppressed the number of Th1 and Th17 cells, as supported by a decreased percentage of CD4(+)/IFN-γ(+) and CD4(+)/IL-17(+) cells, respectively.

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Molecular Weight (MW)229.23
Molecular FormulaC12H11N3O2
CAS No.21802-37-9
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

SynonymsCarulomycin A; AC1NTHG8; AC1N-THG8; AC1N THG8 NSC-114341; NSC114341; NSC 114341; HE185727; HE 185727; HE-185727; Caerulomycin A
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM4.3624 mL21.8122 mL43.6243 mL87.2486 mL
5mM0.8725 mL4.3624 mL8.7249 mL17.4497 mL
10mM0.4362 mL2.1812 mL4.3624 mL8.7249 mL
20mM0.2181 mL1.0906 mL2.1812 mL4.3624 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.